- Kyoto University, Kyoto, Japan Ph.D., 1992 in Chemistry, Supervisor: Dr. Kazuyuki Akasaka
- Ontario Cancer Institute Postdoctoral Fellow 1995 – 1997
Education & Training
Ilina TV, Xi Z, Brosenitsch T, Sluis-Cremer N, Ishima R. Large Multidomain Protein NMR: HIV-1 Reverse Transcriptase Precursor in Solution, Int J Mol Sci, 2020, 21, 9545. PMID: 33333923
Khan SN, Persons JD, Guerrero M, Ilina TV, Oda M, Ishima R. A synergy of activity, stability, and inhibitor-interaction of HIV-1 protease mutants evolved under drug-pressure, Protein Sci, 2021, 30, 571-582, PMID: 33314454
Xi Z, Liu X, Lin R, Persons JD, Ilina TV, Li W, Dimitrov DS, Ishima R. The reduced form of the antibody CH2 domain. Protein Sci, 2021, 30, 1895-1903, PMID: 34107549
Baek DS, Kim YJ, Vergara S, Conard A, Adams C, Calero G, Ishima R, Mellors JW, Dimitrov DS. A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo, Cancer Lett, 2022. 525, 97-107. PMID: 34740610
Xi Z, Ilina TV, Guerrero M, Fan L, Sluis-Cremer N, Wang YX, Ishima R. Relative domain orientation of the L289K HIV-1 reverse transcriptase monomer. Protein Sci. 2022. 31. E4307. PMID: 35481647
Sun Z, Chu X, Adams C, Ilina TV, Guerrero M, Lin G, Chen C, Dontcho J, Ishima R, Wei L, Mellors JW, Calero G, Dimitrov DS. Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate. Mol Ther Oncolytics, 2023, 31, 100726. PMID: 37771390
Chagas BCA, Zhou X, Guerrero M, Ilina TV, Ishima R. Interplay between protease and reverse transcriptase dimerization in a model HIV-1 polyprotein. Protein Sci, 2024, 33, e5080, PMID: 38896002
The major objective of our research has been to determine protein structure and dynamics using nuclear magnetic resonance (NMR); spectroscopy, in order to elucidate protein function particularly relating to protein-ligand interactions.
Conformational dynamics and inhibitor responses of HIV-1 RT RNase H in solution
10/01/13 – 08/31/17
National Institutes of Health
R01
Pittsburgh Center for HIV Protein Interactions (PCHPI)
09/30/12 – 07/31/17
National Institutes of Health
P50