Welcome. 

Welcome to the website of the Department of Structural Biology at the University of Pittsburgh. 

The Department of Structural Biology at the University of Pittsburgh School of Medicine is located in Biomedical Science Tower 3.  We currently have twelve faculty members working in the fields of Cryo EM, NMR, X-Ray Crystallography, and Biochemistry.

Learn more about our department and the exciting work that we do by navigating with the menu on the left. Do not hesitate to contact us if you do not find the information that you are looking for on these pages.

If you are interested in pursuing an advanced degree in Structural Biology please take a look site at the Molecular Biophysics and Structural Biology Graduate Program.


Angela M. Gronenborn, Ph.D.
UPMC Rosalind Franklin Professor and Chair 
Department of Structural Biology 
Distinguished Professor of Structural Biology 
University of Pittsburgh School of Medicine 
Professor of Bioengineering 
Swanson School of Engineering

 


 

 

 

 

 

 

Angela Gronenborn
UPMC Rosalind Franklin Professor and Chair
Department of Structural Biology

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412-648-9959

HIV
NMR Studies

 

Jinwoo Ahn
Assistant Professor

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412-383-6933

Protein Biochemistry

 

James Conway
Professor

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412-383-9847

Cryo-Electron Microscopy

 

Andrew Hinck
Professor

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412-648-8533

NMR Studies

 

Rieko Ishima
Associate Professor

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412-648-9056

NMR Studies

 

Patrick van der Wel
Associate Professor

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412-383-9896

Solid-state NMR Studies 

  Ronald Wetzel
Professor Emeritus

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412-383-5271
 

Yan Xu
Professor

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412-648-9922

Anesthesiology 

 

Guillermo Calero
Assistant Professor

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412-383-5319

X-ray Crystallography  

 

Peijun Zhang
Associate Professor

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412-383-5907

Cryo-Electron Microscopy

       
       
       

 

Yan Xu 


Research efforts in Dr. Xu's group are directed to three projects: (1); membrane protein structures and dynamics by NMR; (2); low-affinity drug interaction with membrane proteins, and (3); gene and stem cell therapy for brain protection and revitalization after cardiac arrest and resuscitation. The current focuses are as follows. For Project 1, NMR is used to determine the transmembrane domain structures of the human glycine receptor, which is the primary inhibitory receptors in the spinal cord and responsible for a wide range of diseases. The long-term goal is to provide the structural basis for novel design of drugs that are disease specific and devoid of side effects. For Project 2, experimental and theoretical approaches are combined to study how low affinity neurological agents, such as alcohol and general anesthetics, exert their effects on the central nervous system at the molecular level. The goal is to shed new lights on the great unsolved mystery of modern medicine: the molecular mechanisms of general anesthesia. For Project 3, new gene therapy strategies are being developed to target a special event called reperfusion injury after cardiac arrest and resuscitation. Recently, Dr. Xu's group combines gene therapy with stem cell therapy using a non-controversial source of stem cells, in an effort to stop and reverse the neuronal loss and to rebuild neuronal circuitry after reperfusion from prolonged cardiac arrest or stroke.
Students in Dr. Xu's laboratory have the opportunity to learn a variety of modern techniques, including expression and purification of membrane proteins, immunohistochemistry, high-resolution nuclear magnetic resonance imaging and spectroscopy, imaging reconstruction, 3-D protein structure calculation, and molecular dynamics simulations.



Department of Anesthesiology
University of Pittsburgh School of Medicine
Biomedical Science Tower 3, Room 2048
3501 Fifth Avenue
Pittsburgh, PA 15260

P 412- 648-9922
F 412-648-8998
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Date PS Reading Lecture Notes Instructor Topic
Aug 25 (M)   1.pdf 2.pdf   Lanni QM I
Aug 27 (W)   1.pdf   Lanni QM II
Aug 29 (F)   1.pdf   Lanni UV absorption
Sep 1 (M)       Labor Day  
Sep 3 (W)   1.pdf   Lanni Fluorescence I
Sep 5 (F)   1.pdf   Lanni Fluorescence II
Sep 8 (M)       Asher Circular Dichroism I
Sep 10 (W)       Asher Circular Dichroism II
Sep 12 (F)       Asher IR/Raman
Sep 15 (M)       Furey Intro Proteins, Exam I (QM-IR/Raman)
Sep 17 (W)   1.pdf 2.pdf   Ishima NMR I
Sep 19 (F)       Ishima NMR II
Sep 22 (M)       Ishima NMR III
Sep 24 (W)       Ishima NMR IV
Sep 26 (F)       Ishima NMR V
Sep 29 (M)       Ishima NMR VI
Oct 1 (W)       Ishima NMR VII
Oct 3 (F)       Ishima NMR vs other spectroscopies
Oct 6 (M)   1.pdf   van der Wel Solid State NMR I
Oct 8 (W)       van der Wel Solid State NMR II
Oct 10 (F)       van der Wel ESR
Oct 13 (M)       Leuba Single molecule I
Oct 15 (W)       Leuba Single molecule II
Oct 17 (F)       CMU Fall Break  
Oct 20 M)       Van Houten Protein-DNA Interactions I
Oct 22 (W)       Van Houten Protein-DNA Interactions II
Oct 24 (F)       Ishima Exam II (NMR-ESR)
Oct 27 (M)          
Oct 29 (W)       BGSA Symposiun  
Oct 30 (Th)       Evilevitch Calorimitry
Oct 31 (F)       Furey X-ray I
Nov 3 (M)       Furey X-ray II
Nov 5 (W)       Furey X-ray III
Nov 7 (F)       Furey X-ray IV
Nov 10 (M)       Furey X-ray V
Nov 12 (W)       Furey X-ray VI
Nov 14 (F)       Furey X-ray VII
Nov 17 (M)       Furey X-ray VIII
Nov 19 (W)       Furey Exam III (Single molecule -Xray)
Nov 21 (F)     1.pdf Conway Electron Microscopy I
Nov 24 (M)     1.pdf Conway Electron Microscopy II
Nov 26 (W)       Thanksgiving  
Nov 28 (F)       Thanksgiving  
Dec 1 (M)     1.pdf Conway Electron Microscopy III
Dec 3 (W)     1.pdf Yates Mass Spec I
Dec 5 (F)     1.pdf Yates Mass Spec II
Dec 8 (M)          
Dec 17 (W)          
Dec 18 (Th)